A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity.

نویسندگان

  • M Palomba
  • L Rossi
  • L Sancineto
  • E Tramontano
  • A Corona
  • L Bagnoli
  • C Santi
  • C Pannecouque
  • O Tabarrini
  • F Marini
چکیده

Herein, we disclose a general and flexible access to spirocyclopropyl oxindoles by a domino Michael/intramolecular nucleophilic substitution pathway with variously substituted vinyl selenones and enolizable oxindoles in aqueous sodium hydroxide solution. The spirocyclopropyl oxindole being a privileged scaffold, some of the synthesized compounds were selected for biological evaluation. Compound showed selective anti-HIV-1 activity thanks to its ability to inhibit the reverse transcriptase.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 14 6  شماره 

صفحات  -

تاریخ انتشار 2016